Yes, I think I have been lucky over the years with the CLO but I know plenty of other people who have been as well. In fact, there is a research group (one of the best in the UK and is made up of scientists and vets) that have got some of the most promising data in this area. Whilst CLO has never solved the problem (some research indicates it is probably better used as a preventative measure rather than a complete cure), but it can (without boring you too much with the biology) provide increased movement and reduces the friction in the joints, thus alleviating arthritic symptoms.
A lot of the research that has gone on this area really only shows mild benefits of any 'natural remedy' and at the end of the day you have to determine whether you would and can treat any pain with natural options or more conventional treatments such as NSAID's.
The research on all dietary supplements (glucosamine) for arthritis is pretty poor, both in the human and veterinary worlds, and the speed with which the research field progresses is very slow - regardless of what companies and the media tell us about certain products.
